CISPOLY
我们的使命

以创新表观遗传技术，
守护女性健康

聚禾生物专注宫颈癌、子宫内膜癌、卵巢癌的 DNA 甲基化早筛早诊，以无创技术填补临床空白，造福中国乃至全球的女性。

了解我们
我们的愿景 · Vision

准确，让病变无所遁形

可及，让筛查触手可及

无创，让女性从容安心

以甲基化创新，让妇科肿瘤早筛惠及每一位女性。

产品矩阵 · Products

三大核心产品，覆盖妇科三大恶性肿瘤

基于 DNA 甲基化的无创早筛早诊产品，针对宫颈癌、子宫内膜癌、卵巢癌提供精准检测方案。

实力与成果

以循证数据，铸就专业信赖

900㎡
GMP 生产车间
1000㎡
研发实验室
千万人次
检测年供应
8项
国内外发明专利
3个
NMPA 注册产品
学术研究 · Research

循证为基，持续创新

开展多项前瞻性多中心临床试验，发表多篇学术文献，以循证依据推动甲基化应用。

PAX1/JAM3 methylation in cervical exfoliated cells: a robust diagnostic biomarker for cervical high-grade lesions associated with vaginal dysbiosis
Effectiveness analysis and clinical application potential exploration of combined detection of PAX1/JAM3 gene methylation in early diagnosis of cervical precancerous lesions
PAX1/JAM3 methylation-a novel biomarker for early detection and accurate management of cervical adenocarcinoma
Utility of PAX1/JAM3 methylation analysis for triage of high-risk HPV-positive individuals
Clinical Utility of Cytological Methylation Assay in Cervical Cancer Screening
Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis
PAX1/JAM3双基因联合甲基化检测在宫颈病变管理中的研究进展
宫颈脱落细胞基因甲基化检测对宫颈高级别病变术后残 留及复发风险的预测意义
Association of PAX1/JAM3 gene methylation, HR-HPV, and TCT with high-grade cervical lesions in a high-risk cohort: a multinomial logistic regression analysis
Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma?
Validation of a cervical CDO1/CELF4 methylation test for endometrial cancer: a prospective paired-sample comparison with intrauterine specimen
Development and validation of hypermethylated gene markers in cervical cytological samples for detecting endometrial cancer (EndoMethy-I trial)
Diagnostic Accuracy and Concordance of Self-Collected Cervical CDO1 and CELF4 Methylation Testing Compared With Physician Sampling for Endometrial Cancer Detection
Clinical Validation of DNA Methylation Detection in Cervical Exfoliated Cells for Endometrial Cancer in Women with Suspected Lesions
CDO1 and CELF4 methylation assay as the dominant predictor of endometrial cancer: A cohort analysis across pre- and post-menopausal cohorts
The triage role of cytological DNA methylation in women with non-16/18, specifically genotyping high-risk HPV infection
Cytologic DNA methylation for managing minimally abnormal cervical cancer screening results
Focused ultrasound ablation for women with cervical lesions: Protocol of a randomized controlled trial
The role of PAX1 and JAM3 methylation in predicting the pathological upgrading of cervical intraepithelial neoplasia before conization
Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis
Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis
PAX1/JAM3基因甲基化在HR-HPV感染女性中宫颈癌的诊断价值
PAX1/JAM3双基因甲基化在宫颈癌筛查及治疗中的应用
PAX1、JAM3甲基化对子宫颈高级别上皮内瘤变诊断的meta分析
宫颈脱落细胞PAX1、JAM3基因甲基化对宫颈上皮内瘤变预测作用的初步研究
Triage performance of DNA methylation for women with high-risk human papillomavirus infection
Prospective Evaluation of Cervical Scrapings CDO1 and CELF4 Methylation (epiHERA?) Assay in Detection of Endometrial Cancer
The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection
PAX1/JAM3 Methylation and HPV Viral Load in Women with Persistent HPV Infection
阴道微生态影响宫颈细胞DNA甲基化水平与宫颈病变的相关性研究
女性阴道自采样本检测PAX1/JAM3双基因甲基化标志物作为子宫颈癌筛查的可行性评估
JAM3基因DNA甲基化在宫颈高级别上皮内瘤变及术后复发预测的临床研究
[A multicenter study on the accuracy of PAX1/JAM3 dual genes methylation testing for screening cervical cancer]
Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non?16/18 human papillomavirus-positive women: a multicenter prospective study in China
Cervical cancer screening: efficacy of PAX1 and JAM3 methylation assay in the triage of atypical squamous cell of undetermined significance (ASC-US)
Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China
Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women
The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China
DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding
禾蔻安双基因甲基化检测在子宫内膜癌筛查中的应用价值
血清中CDO1基因与HOXA9基因启动子甲基化高表达在卵巢癌诊断中的意义
High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients
DNA甲基化检测在绝经后女性子宫内膜癌筛查中的应用价值
DNA甲基化检测在育龄期异常子宫出血女性子宫内膜癌诊断中的应用价值
Hypermethylated CDO1 and CELF4 in cytological specimens as triage strategy biomarkers in endometrial malignant lesions.
PAX1/JAM3 methylation in cervical exfoliated cells: a robust diagnostic biomarker for cervical high-grade lesions associated with vaginal dysbiosis
Effectiveness analysis and clinical application potential exploration of combined detection of PAX1/JAM3 gene methylation in early diagnosis of cervical precancerous lesions
PAX1/JAM3 methylation-a novel biomarker for early detection and accurate management of cervical adenocarcinoma
Utility of PAX1/JAM3 methylation analysis for triage of high-risk HPV-positive individuals
Clinical Utility of Cytological Methylation Assay in Cervical Cancer Screening
Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis
PAX1/JAM3双基因联合甲基化检测在宫颈病变管理中的研究进展
宫颈脱落细胞基因甲基化检测对宫颈高级别病变术后残 留及复发风险的预测意义
Association of PAX1/JAM3 gene methylation, HR-HPV, and TCT with high-grade cervical lesions in a high-risk cohort: a multinomial logistic regression analysis
Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma?
Validation of a cervical CDO1/CELF4 methylation test for endometrial cancer: a prospective paired-sample comparison with intrauterine specimen
Development and validation of hypermethylated gene markers in cervical cytological samples for detecting endometrial cancer (EndoMethy-I trial)
Diagnostic Accuracy and Concordance of Self-Collected Cervical CDO1 and CELF4 Methylation Testing Compared With Physician Sampling for Endometrial Cancer Detection
Clinical Validation of DNA Methylation Detection in Cervical Exfoliated Cells for Endometrial Cancer in Women with Suspected Lesions
CDO1 and CELF4 methylation assay as the dominant predictor of endometrial cancer: A cohort analysis across pre- and post-menopausal cohorts
The triage role of cytological DNA methylation in women with non-16/18, specifically genotyping high-risk HPV infection
Cytologic DNA methylation for managing minimally abnormal cervical cancer screening results
Focused ultrasound ablation for women with cervical lesions: Protocol of a randomized controlled trial
The role of PAX1 and JAM3 methylation in predicting the pathological upgrading of cervical intraepithelial neoplasia before conization
Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis
Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis
PAX1/JAM3基因甲基化在HR-HPV感染女性中宫颈癌的诊断价值
PAX1/JAM3双基因甲基化在宫颈癌筛查及治疗中的应用
PAX1、JAM3甲基化对子宫颈高级别上皮内瘤变诊断的meta分析
宫颈脱落细胞PAX1、JAM3基因甲基化对宫颈上皮内瘤变预测作用的初步研究
Triage performance of DNA methylation for women with high-risk human papillomavirus infection
Prospective Evaluation of Cervical Scrapings CDO1 and CELF4 Methylation (epiHERA?) Assay in Detection of Endometrial Cancer
The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection
PAX1/JAM3 Methylation and HPV Viral Load in Women with Persistent HPV Infection
阴道微生态影响宫颈细胞DNA甲基化水平与宫颈病变的相关性研究
女性阴道自采样本检测PAX1/JAM3双基因甲基化标志物作为子宫颈癌筛查的可行性评估
JAM3基因DNA甲基化在宫颈高级别上皮内瘤变及术后复发预测的临床研究
[A multicenter study on the accuracy of PAX1/JAM3 dual genes methylation testing for screening cervical cancer]
Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non?16/18 human papillomavirus-positive women: a multicenter prospective study in China
Cervical cancer screening: efficacy of PAX1 and JAM3 methylation assay in the triage of atypical squamous cell of undetermined significance (ASC-US)
Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China
Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women
The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China
DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding
禾蔻安双基因甲基化检测在子宫内膜癌筛查中的应用价值
血清中CDO1基因与HOXA9基因启动子甲基化高表达在卵巢癌诊断中的意义
High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients
DNA甲基化检测在绝经后女性子宫内膜癌筛查中的应用价值
DNA甲基化检测在育龄期异常子宫出血女性子宫内膜癌诊断中的应用价值
Hypermethylated CDO1 and CELF4 in cytological specimens as triage strategy biomarkers in endometrial malignant lesions.
临床指南 · Guidelines

获多项指南与共识推荐

多部国家级临床指南与专家共识支持产品在临床上的规范化应用。

子宫内膜癌
2026

子宫内膜癌基因甲基化筛查技术临床应用专家共识（2026版）

中华医学杂志

DOI: 10.3760/cma.j.cn112137-20260301-00576

《子宫内膜癌基因甲基化筛查技术临床应用专家共识（2026版）》由多家学会牵头、多学科专家经多轮共识会议制订，针对我国子宫内膜癌发病率上升、防控形势严峻的背景，围绕已获国家药品监督管理局批准的基因甲基化检测技术，阐述其用于有症状、风险增加及高风险三类人群的筛查流程、风险评估与管理策略并给出推荐意见，旨在规范临床应用、提高早发现早诊断早治疗水平。

宫颈癌
2026

European Society of Gynaecological Oncology/European Network of Gynaecological Advocacy Groups Position on risk-based cervical cancer screening

Intl Journal of Gynecological Cancer

DOI: 10.1016/j.ijgc.2026.104794

ESGO 2026年立场声明推荐以HPV DNA检测替代细胞学作为宫颈癌初筛手段，以提供更强保护；倡导性别中立HPV疫苗接种加速群体免疫，尤其在覆盖率未达WHO目标时；建议HPV分型结合年龄与筛查史进行个体化风险评估，并认为甲基化检测有望在全分子化筛查模式中显著减少不必要的阴道镜转诊。

宫颈癌
2025

子宫颈癌PAX1联合JAM3双基因甲基化检测流程、报告及临床应用专家共识

中华检验医学杂志

DOI: 10.3760/cma.j.cn114452-20240303-00105

本共识（2025年）由中国中西医结合学会检验医学专业委员会联合多学（协）会组织检验、病理、妇产多学科专家制定，全面梳理子宫颈癌PAX1联合JAM3双基因甲基化检测的实验室操作流程、质控标准与样本采集处理，并提出检测报告及临床应用建议，旨在推动宫颈癌甲基化检测在实验室与临床的规范化应用、保障检测结果准确可靠。

最新动态 · News

聚禾动态

学术成果、指南共识、会议研讨、健康科普，持续更新。